Eight-day Inpatient Directly Observed Therapy for Antiretroviral Therapy (ART) Failure: A Tool For Preventing Unnecessary ART Changes and Optimizing Adherence Support. (11th July 2019)

• Record Type: Journal Article
• Authors: Winchester, Nicole E; Maldarelli, Frank; Mejia, Yolanda; Dee, Nicola; Dewar, Robin; Laidlaw, Elizabeth; Kuriakose, Safia S; Stoll, Pamela; Proschan, Michael; Lane, H Clifford; Pau, Alice K
• Is Part Of: Clinical infectious diseases. Volume 70:Number 6(2020)
• Page Start: 1222
• Page End: 1225
• Publication Date: 2019-07-11
• Subjects: antiretroviral therapy -- viral failure -- adherence -- directly observed therapy -- drug resistance; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciz590
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Eight-day inpatient directly observed therapy confirmed nonadherence as the major cause of virologic failure for 9 (45%) of 20 highly treatment-experienced persons with human immunodeficiency virus, extensive antiretroviral drug resistance, and high self-reported adherence rates, preventing unnecessary regimen changes.