Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections. (28th August 2017)

• Record Type: Journal Article
• Authors: Celestin, Arthur R; Odom, Stephen R; Angelidou, Konstantia; Evans, Scott R; Coimbra, Raul; Guidry, Christopher A; Cuschieri, Joseph; Banton, Kaysie L; O'Neill, Patrick J; Askari, Reza; Namias, Nicholas; Duane, Therèse M; Claridge, Jeffrey A; Dellinger, E Patchen; Sawyer, Robert A; Cook, Charles H
• Is Part Of: Clinical infectious diseases. Volume 65:Number 9(2017)
• Page Start: 1577
• Page End: 1579
• Publication Date: 2017-08-28
• Subjects: antibiotic resistance -- desirability of outcome ranking -- duration of antibiotic therapy -- surgical infection -- intra-abdominal infection; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/cix569
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Desirability of outcome ranking and response adjusted for duration of antibiotic risk (DOOR/RADAR) are novel and innovative methods of evaluating data in antibiotic trials. We analyzed data from a noninferiority trial of short-course antimicrobial therapy for intra-abdominal infection (STOP-IT), and results suggest global superiority of short-duration therapy for intra-abdominal infections.