Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium. (12th June 2019)

• Record Type: Journal Article
• Authors: Manion, Maura; Dimitrova, Dimana; Pei, Luxin; Gea-Banacloche, Juan; Zelazny, Adrian; Lisco, Andrea; Zerbe, Christa; Freeman, Alexandra F; Holland, Steven M; Kanakry, Christopher G; Kanakry, Jennifer A; Sereti, Irini
• Is Part Of: Clinical infectious diseases. Volume 70:Number 4(2020)
• Page Start: 676
• Page End: 679
• Publication Date: 2019-06-12
• Subjects: immune reconstitution -- bone marrow transplantation -- primary immunodeficiency -- Mycobacterium avium; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciz507
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.