A 17-Year-Old Boy With Right Face Palsy, Left Leg Weakness, and Lytic Skull-Bone Lesions. (24th January 2018)

• Record Type: Journal Article
• Authors: Akinboyo, Ibukunoluwa C; Crane, Genevieve M; Chen, Lingling; Arav-Boger, Ravit
• Is Part Of: Journal of the Pediatric Infectious Diseases Society. Volume 7:Number 4(2018:Dec.)
• Page Start: 350
• Page End: 354
• Publication Date: 2018-01-24
• Subjects: adult T-cell leukemia/lymphoma -- human T-cell lymphotropic virus -- perinatal HTLV exposure -- tropical spastic paraparesis; Communicable diseases in children -- Periodicals; Children -- Diseases -- Periodicals; 618.929
• DOI: 10.1093/jpids/pix101
• Languages: English
• ISSNs: 2048-7193

Abstract

Abstract: Human T-cell lymphotropic virus (HTLV), an infection that is endemic in certain parts of Asia, Africa, and South America, has been associated with malignancy and neurological deficits. Here, we describe a pediatric patient with chronic HTLV-I infection who developed complications associated with HTLV-I (ie, adult T-cell leukemia/lymphoma and HTLV-I–associated myelopathy/tropical spastic paraparesis). To our knowledge, this presentation in a child has never been described. The patient underwent a bone marrow transplant and, at the time of this writing, was in remission. This case report highlights the fact that HTLV-related complications, previously expected to occur after decades of infection, also can occur in pediatric patients, particularly those who acquired HTLV-I perinatally.