Comprehensive Clinical and Laboratory Follow-up of a Female Patient With Ebola Virus Disease: Sierra Leone Ebola Virus Persistence Study. (26th February 2019)

• Record Type: Journal Article
• Authors: Liu, William J; Sesay, Foday R; Coursier, Antoine; Knust, Barbara; Marrinan, Jaclyn E; Whitmer, Shannon; McDonald, Suzanna L R; Gaillard, Philippe; Liu, Yang; Su, Qiudong; Zhang, Yong; Crozier, Ian; Ariyarajah, Archchun; Carino, Marylin; Massaquoi, Thomas; Broutet, Nathalie; Xu, Wenbo; Wu, Guizhen; Ströher, Ute; Gao, George F; Formenty, Pierre; Sahr, Foday; Deen, Gibrilla F
• Is Part Of: Open forum infectious diseases. Volume 6:Number 3(2019)
• Publication Date: 2019-02-26
• Subjects: clinical sequelae -- Ebola virus -- immune responses -- virus genome -- virus persistence; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofz068
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: The clinical, virologic, and immunologic findings in a female Ebola virus disease patient are described. During the long-term follow-up, Ebola virus RNA was detectable in vaginal fluid before 36 days after symptom onset, with nearly an identical genome sequence as in acute phase blood. Ebola-specific T cells retained activation at 56 days after disease onset.