Hepatitis E Virus–Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing. (13th June 2017)

• Record Type: Journal Article
• Authors: Murkey, Jamie A.; Chew, Kara W.; Carlson, Margrit; Shannon, Chelsea L.; Sirohi, Deepika; Sample, Hannah A.; Wilson, Michael R.; Vespa, Paul; Humphries, Romney M.; Miller, Steve; Klausner, Jeffrey D.; Chiu, Charles Y.
• Is Part Of: Open forum infectious diseases. Volume 4:Number 3(2017)
• Publication Date: 2017-06-13
• Subjects: encephalitis -- hepatitis E virus -- lung transplant -- meningitis -- metagenomic next-generation sequencing (mNGS); Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofx121
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation.