Concise Review: Different Mesenchymal Stromal/Stem Cell Populations Reside in the Adult Kidney. (29th October 2014)

• Record Type: Journal Article
• Authors: Bruno, Stefania; Chiabotto, Giulia; Camussi, Giovanni
• Is Part Of: Stem cells translational medicine. Volume 3:Number 12(2014)
• Page Start: 1451
• Page End: 1455
• Publication Date: 2014-10-29
• Subjects: Kidney -- Stem cells -- Tissue resident mesenchymal stem cells -- Glomeruli; Stem cells -- Periodicals; Regenerative medicine -- Periodicals; Periodicals; 616.0277405
• DOI: 10.5966/sctm.2014-0142
• Languages: English
• ISSNs: 2157-6564

Abstract

Abstract : In adults, a mesenchymal stromal/stem cell (MSC)-like population has been demonstrated in different compartments of human and murine nephrons. The evidence of an MSC presence within the adult kidney and the potential contribution of MSCs to the turnover of renal cells and injury repair is discussed. Abstract: : During fetal life, mesenchymal stromal/stem cells (MSCs) surround glomeruli and tubules and contribute to the development of the renal interstitium by secretion of growth factors that drive nephron differentiation. In the adult, an MSC-like population has been demonstrated in different compartments of human and murine nephrons. After injury, these cells might provide support for kidney regeneration by recapitulating the role they have in embryonic life. In this short review, we discuss the evidence of an MSC presence within the adult kidney and their potential contribution to the turnover of renal cells and injury repair.