Detection of Nicotine and Nicotine Metabolites in Units of Banked Blood. Issue 5 (3rd February 2019)

• Record Type: Journal Article
• Authors: Wiencek, Joesph R; Gehrie, Eric A; Keiser, Amaris M; Szklarski, Penny C; Johnson-Davis, Kamisha L; Booth, Garrett S
• Is Part Of: American journal of clinical pathology. Volume 151:Issue 5(2019)
• Page Start: 516
• Page End: 521
• Publication Date: 2019-02-03
• Subjects: Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; 616.07
• DOI: 10.1093/ajcp/aqy176
• Languages: English
• ISSNs: 0002-9173

Abstract

Abstract: Objectives: To determine the concentrations of nicotine and nicotine metabolites in RBC units as a means to estimate the point prevalence of exposure within the healthy donor pool. Methods: Segments from 105 RBC units were tested for the presence of nicotine, cotinine, or trans -3ʹ-hydroxycotinine by liquid chromatography–tandem mass spectrometry. Results: Of the 20 (19%) units that contained detectable concentrations of nicotine, cotinine, or trans -3ʹ-hydroxycotinine, 19 (18.1%) contained concentrations consistent with the use of a nicotine-containing product within 48 hours of specimen collection. One RBC unit contained nicotine concentrations consistent with passive exposure. Conclusions: Chemicals from nicotine-containing products are detectable within the US RBC supply. Further investigation is needed to determine the risks of transfusion-associated exposure to nicotine and other tobacco-associated chemicals among vulnerable patient populations such as neonates.