Seroprevalence of Powassan Virus Infection in an Area Experiencing a Cluster of Disease Cases: Sussex County, New Jersey, 2019. (17th January 2022)

• Record Type: Journal Article
• Authors: Vahey, Grace M; Wilson, Nicolette; McDonald, Emily; Fitzpatrick, Kelly; Lehman, Jennifer; Clark, Sandhya; Lindell, Kristine; Pastula, Daniel M; Perez, Stephen; Rhodes, Heather; Gould, Carolyn V; Staples, J Erin; Cervantes, Kim; Martin, Stacey W
• Is Part Of: Open forum infectious diseases. Volume 9:Number 3(2022)
• Publication Date: 2022-01-17
• Subjects: arboviral -- meningoencephalitis -- neuroinvasive -- Powassan virus -- seroprevalence; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofac023
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: In 2019, a geographically focal cluster of 3 Powassan virus neuroinvasive disease cases occurred in New Jersey. We conducted a serosurvey of 273 adult area residents and estimated that immunoglobulin M seroprevalence was 0.31% (95% confidence interval [CI], .04%–1.00%) and 23% (95% CI, 7%–100%) of infections result in neuroinvasive disease. Abstract : A serosurvey of 273 residents of a New Jersey community with several recent Powassan virus neuroinvasive disease cases estimated IgM seroprevalence at <1% and that roughly one-quarter of infections result in neuroinvasive disease.