Efficacy of Recombinant Human Interleukin 7 in a Patient With Severe Lymphopenia-Related Progressive Multifocal Leukoencephalopathy. (26th August 2014)

• Record Type: Journal Article
• Authors: Gasnault, Jacques; de Goër de Herve, Marie-Ghislaine; Michot, Jean-Marie; Hendel-Chavez, Houria; Seta, Vannina; Mazet, Anne-Aurélie; Croughs, Thérèse; Stankoff, Bruno; Bourhis, Jean-Henri; Lambotte, Olivier; Delfraissy, Jean-François; Taoufik, Yassine
• Is Part Of: Open forum infectious diseases. Volume 1:Number 2(2014)
• Publication Date: 2014-08-26
• Subjects: bone marrow transplantation -- JC virus -- progressive multifocal leukoencephalopathy -- recombinant interleukin-7 -- T-cell lymphopenia; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofu074
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: In this study, we report the case of a patient with profound lymphopenia after allogenic bone marrow transplantation who developed severe progressive multifocal leukoencephalopathy. Single-agent recombinant human interleukin-7 therapy was associated with restoration of anti-John Cunningham polyomavirus (JCV) T-cell responses, JCV clearance from cerebrospinal fluid, and a dramatic clinical improvement.