Genomic Landscape of Adult and Pediatric BCR‐ABL1‐Like B‐Lymphoblastic Leukemia Using Parallel DNA and RNA Sequencing. (4th September 2018)

• Record Type: Journal Article
• Authors: Severson, Eric A.; Vergilio, Jo‐Anne; Gay, Laurie M.; Daniel, Sugganth; Hemmerich, Amanda C.; Elvin, Julia A.; Britt, Nicholas; Nahas, Michelle; Cohen, Michael B.; Brown, Charlotte; Sathyan, Pratheesh; Rankin, Andrew; Miller, Vincent; Ross, Jeffrey S.; Ramkissoon, Shakti H.
• Is Part Of: Oncologist. Volume 24:Number 3(2019)
• Page Start: 372
• Page End: 374
• Publication Date: 2018-09-04
• Subjects: Oncology -- Periodicals; Tumors -- Periodicals; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Oncology; Tumors; Neoplasms; Electronic journals; Periodicals; Periodicals; 616.994
• DOI: 10.1634/theoncologist.2018-0272
• Languages: English
• ISSNs: 1083-7159

Abstract

Abstract: : BCR‐ABL1‐like B‐Acute Lymphoblastic Leukemia (B‐ALL) is a subset of B‐ALL with a poor prognosis that is found in all age groups. Definitive identification of these patients is difficult in routine clinical practice as gene expression profiling, the gold standard test, is not widely available. Comprehensive genomic profiling performed on 450 patients with extensive fusion profiling revealed a wide range of genomic alterations which were consistent with a classification of BCR‐ABL1‐like B‐ALL in 29% of cases. This manuscript highlights a clinically available alternative method for identifying a large subset of patients with BCR‐ABL1‐like B‐ALL. Abstract : BCR‐ABL1‐like B‐lymphoblastic leukemia, also termed Philadelphia‐like B‐acute lymphoblastic leukemia (Ph‐like B‐ALL), shares a gene expression profile similar to BCR‐ABL1‐positive B‐ALL1 but lacks BCR‐ABL1 fusion. Because Ph‐like status confers a poor prognosis, identification of Ph‐like B‐ALL cases is important. This brief communication reports 450 cases of B‐ALL evaluated by genomic profiling.