Venous Thromboembolism in Patients with Sarcoma: A Retrospective Study. (26th September 2018)

• Record Type: Journal Article
• Authors: Alcindor, Thierry; Al‐Fakeeh, Ali; Goulding, Krista; Solymoss, Susan; Ste‐Marie, Nathalie; Turcotte, Robert
• Is Part Of: Oncologist. Volume 24:Number 3(2019)
• Page Start: e111
• Page End: e114
• Publication Date: 2018-09-26
• Subjects: Oncology -- Periodicals; Tumors -- Periodicals; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Oncology; Tumors; Neoplasms; Electronic journals; Periodicals; Periodicals; 616.994
• DOI: 10.1634/theoncologist.2018-0081
• Languages: English
• ISSNs: 1083-7159

Abstract

Abstract: Background: Little has been published about the association of venous thromboembolism (VTE) and sarcoma. In this study, we sought to identify clinical features of patients with sarcoma presenting at least one VTE episode. Methods: Our study was a retrospective case–control study of a single‐institution database with univariate and multivariate analysis using chi‐square and Student's t test. A p value less than .05 was considered significant. Results: The overall incidence of VTE in patients with sarcoma was 7.9%. Predictive factors identified by multivariate analysis were metastatic disease and administration of chemotherapy. It was not statistically possible to correlate the risk of VTE with specific sarcoma subtypes, but observations suggested malignant peripheral nerve sheath tumor, osteosarcoma, and liposarcoma as having the highest propension. Conclusion: VTE is not infrequent in patients with sarcoma. Adoption of common guidelines for cancer‐associated thrombosis is recommended. Abstract : Risk factors and management guidelines for venous thromboembolism (VTE) are well established; however, little clinical research has been undertaken on VTE in sarcomas. This retrospective study aimed to identify the clinical characteristics of adult sarcoma patients with VTE.