Adult T-Cell Leukemia/Lymphoma in a Caucasian Patient After Sexual Transmission of Human T-Cell Lymphotropic Virus Type 1. (6th March 2015)

• Record Type: Journal Article
• Authors: Sibon, David; Cassar, Olivier; Duga, Isabelle; Brouzes, Chantal; Ghez, David; Pasquier, Christophe; Sibon, Claire; Desrames, Alexandra; Mortreux, Franck; Wattel, Eric; Bazarbachi, Ali; Gessain, Antoine; Hermine, Olivier
• Is Part Of: Open forum infectious diseases. Volume 2:Number 2(2015)
• Publication Date: 2015-03-06
• Subjects: ATLL -- HTLV-1 -- HTLV-1 transmission -- lymphoma -- viral genotyping; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofv032
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Adult T-cell leukemia/lymphoma (ATLL), a T-cell neoplasm caused by human T-cell lymphotropic virus type 1 (HTLV-1), develops in the majority of cases in individuals who were infected with HTLV-1 as young children, by their mother during prolonged breastfeeding. We report the case of a Caucasian French man, whose parents were HTLV-1-seronegative and who developed ATLL after HTLV-1 sexual transmission by a Cameroonian woman. This hypothesis was corroborated by genotyping of the patient's virus, which revealed an HTLV-1B strain, found only in Central Africa, especially in Cameroon. Thus, ATLL may develop after HTLV-1 infection during adulthood, outside breastfeeding.