Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1. (28th December 2015)

• Record Type: Journal Article
• Authors: Béguelin, C.; Vázquez, M.; Bertschi, M.; Yerly, S.; de Jong, D.; Gutbrod, K.; Rauch, A.; Cusini, A.
• Is Part Of: Open forum infectious diseases. Volume 3:Number 1(2016)
• Publication Date: 2015-12-28
• Subjects: central nervous system -- HIV -- K65R -- viral escape -- multidrug-resistant; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofv210
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimization with drugs with high CNS penetration led to viral suppression in the CSF, regression of ataxia, and improvement of neurocognitive symptoms.