Diagnosis and Genotyping of Coxiella burnetii Endocarditis in a Patient with Prosthetic Pulmonary Valve Replacement Using Next-Generation Sequencing of Plasma Microbial Cell-Free DNA. (1st June 2019)

• Record Type: Journal Article
• Authors: Kondo, Maiko; Dalai, Sudeb C; Venkatasubrahmanyam, Shivkumar; Eisenberg, Nell; Robinson, Brian D; Westblade, Lars F; Marks, Kristen M
• Is Part Of: Open forum infectious diseases. Volume 6:Number 6(2019)
• Publication Date: 2019-06-01
• Subjects: Coxiella burnetii -- endocarditis -- next-generation sequencing -- plasma microbial cell-free DNA -- Q fever; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofz242
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Determining the causative etiology of culture-negative endocarditis can be challenging. We performed next-generation sequencing of plasma microbial cell-free DNA to facilitate rapid diagnosis and genotyping of Coxiella burnetii in a patient with culture-negative endocarditis of a prosthetic pulmonary valve, enabling early targeted treatment prior to valve replacement surgery.