Benefit-risk Evaluation for Diagnostics: A Framework (BED-FRAME). (18th May 2016)

• Record Type: Journal Article
• Authors: Evans, Scott R.; Pennello, Gene; Pantoja-Galicia, Norberto; Jiang, Hongyu; Hujer, Andrea M.; Hujer, Kristine M.; Manca, Claudia; Hill, Carol; Jacobs, Michael R.; Chen, Liang; Patel, Robin; Kreiswirth, Barry N.; Bonomo, Robert A.
• Editors: Weinstein, Robert A.
• Is Part Of: Clinical infectious diseases. Volume 63:Number 6(2016)
• Page Start: 812
• Page End: 817
• Publication Date: 2016-05-18
• Subjects: benefit-risk -- diagnostics -- diagnostic yield -- pragmatism; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciw329
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract : Pragmatic evaluation of diagnostics depends on prevalence and the relative importance of potential errors. Benefit-Risk Evaluation of Diagnostics: A Framework provides a tool for communicating the expected clinical impact of diagnostic application and is a useful fundamental supplement to the standard analysis of diagnostic studies. Abstract: The medical community needs systematic and pragmatic approaches for evaluating the benefit-risk trade-offs of diagnostics that assist in medical decision making. Benefit-Risk Evaluation of Diagnostics: A Framework (BED-FRAME) is a strategy for pragmatic evaluation of diagnostics designed to supplement traditional approaches. BED-FRAME evaluates diagnostic yield and addresses 2 key issues: (1) that diagnostic yield depends on prevalence, and (2) that different diagnostic errors carry different clinical consequences. As such, evaluating and comparing diagnostics depends on prevalence and the relative importance of potential errors. BED-FRAME provides a tool for communicating the expected clinical impact of diagnostic application and the expected trade-offs of diagnostic alternatives. BED-FRAME is a useful fundamental supplement to the standard analysis of diagnostic studies that will aid in clinical decision making.