Muscle-derived factors influencing bone metabolism. (March 2022)

• Record Type: Journal Article
• Authors: Gries, Kevin J.; Zysik, Victoria S.; Jobe, Tyler K.; Griffin, Nicole; Leeds, Benjamin P.; Lowery, Jonathan W.
• Is Part Of: Seminars in cell & developmental biology. Volume 123(2022)
• Page Start: 57
• Page End: 63
• Publication Date: 2022-03
• Subjects: Myokine -- Skeletal muscle -- Bone -- Exercise -- Crosstalk; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2021.10.009
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: A significant amount of attention has been brought to the endocrine-like function of skeletal muscle on various tissues, particularly with bone. Several lines of investigation indicate that the physiology of both bone and muscle systems may be regulated by a given stimulus, such as exercise, aging, and inactivity. Moreover, emerging evidence indicates that bone is heavily influenced by soluble factors derived from skeletal muscle (i.e ., muscle-to-bone communication). The purpose of this review is to discuss the regulation of bone remodeling (formation and/or resorption) through skeletal muscle-derived cytokines (hereafter myokines) including the anti-inflammatory cytokine METRNL and pro-inflammatory cytokines (e.g., TNF-α, IL-6, FGF-2 and others). Our goal is to highlight possible therapeutic opportunities to improve muscle and bone health in aging.