Varicella Zoster Virus Pneumonitis and Brainstem Encephalitis Without Skin Rash in an Immunocompetent Adult. (6th August 2014)

• Record Type: Journal Article
• Authors: Nandhagopal, Ramachandiran; Khmeleva, Nelly; Jayakrishnan, B.; White, Teresa; Al Azri, Faisal; George, Jojy; Heintzman, Anna; Al Zeedy, Khalfan; Rorke-Adams, Lucy; Gujjar, Arunodaya R.; Schmid, D. Scott; Al-Asmi, Abdullah; Nagel, Maria A.; Jacob, Poovathoor Chacko; Gilden, Don
• Is Part Of: Open forum infectious diseases. Volume 1:Number 2(2014)
• Publication Date: 2014-08-06
• Subjects: absence of rash -- brainstem encephalitis -- pneumonitis -- VZV; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofu064
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Varicella zoster virus (VZV) pneumonitis and brainstem encephalitis developed in an immunocompetent adult without rash. Chest computed tomography exhibited nodularity; lung biopsy revealed multinucleated giant cells, Cowdry A inclusions, VZV antigen, and DNA. Varicella zoster virus central nervous system disease was verified by cerebrospinal fluid (CSF) anti-VZV IgG antibody with reduced serum/CSF ratios.