Emergence of Multidrug-Resistant Influenza A(H1N1)pdm09 Virus Variants in an Immunocompromised Child Treated With Oseltamivir and Zanamivir. (5th May 2015)

• Record Type: Journal Article
• Authors: Tamura, Daisuke; DeBiasi, Roberta L.; Okomo-Adhiambo, Margaret; Mishin, Vasiliy P.; Campbell, Angela P.; Loechelt, Brett; Wiedermann, Bernhard L.; Fry, Alicia M.; Gubareva, Larisa V.
• Is Part Of: Journal of infectious diseases. Volume 212:Number 8(2015:Oct. 15)
• Page Start: 1209
• Page End: 1213
• Publication Date: 2015-05-05
• Subjects: neuraminidase -- drug resistance -- pyrosequencing -- oseltamivir -- zanamivir; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiv245
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Prolonged treatment of an immunocompromised child with oseltamivir and zanamivir for A(H1N1)pdm09 virus infection led to the emergence of viruses carrying H275Y and/or E119G in the neuraminidase (NA). When phenotypically evaluated by NA inhibition, the dual H275Y-E119G substitution caused highly reduced inhibition by 4 NA inhibitors: oseltamivir, zanamivir, peramivir, and laninamivir.