Gasdermin Pore Forming Activities that Promote Inflammation from Living and Dead Cells. Issue 4 (28th February 2022)

• Record Type: Journal Article
• Authors: Cao, Anh; Kagan, Jonathan C.
• Is Part Of: Journal of molecular biology. Volume 434:Issue 4(2022)
• Publication Date: 2022-02-28
• Subjects: innate immunity -- gasdermin -- inflammasomes -- IL-1 -- pyroptosis; Molecular biology -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Bacteriology -- Periodicals; Molecular Biology -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biologie -- Périodiques; Biochimie -- Périodiques; Moleculaire biologie; Biochemistry; Biology; Molecular biology; Periodicals; 572.805
• DOI: 10.1016/j.jmb.2021.167427
• Languages: English
• ISSNs: 0022-2836

Abstract

Graphical abstract: Highlights: Gasdermins are ancient pore forming proteins. Gasdermins function as channels for cytokine secretion or mediators of pyroptosis. Multiple levels of regulation control gasdermin pore forming activities. Abstract: Gasdermins are proteins that can self-assemble into membrane channels (also known as pores). These pores can serve as conduits for the secretion of cytosolic molecules, with the most commonly studied being members of the interleukin-1 family of cytokines. However, gasdermin pore forming activities must be tightly regulated, as the channels that they form can lead to a lytic form of cell death known as pyroptosis. Recent studies have revealed multiple mechanisms that control gasdermin activities within cells and identified gasdermin proteins in organisms as diverse as bacteria, humans and yeast. In this Review, we discuss the molecular and cellular mechanisms that regulate gasdermin pore formation. These mechanisms of gasdermin regulation likely explain the flexibility of these proteins to display cell type specific (and potentially organism specific) functions.