Ag-substituted octacalcium phosphate blocks that exhibit high osteoconductivity and high antibacterial activity toward various pathogens. (March 2022)

• Record Type: Journal Article
• Authors: Sugiura, Yuki; Ono, Fumiko; Nohara, Masakatsu; Horino, Reina; Kutara, Kenji; Kanda, Teppei; Oowada, Kazuo; Horie, Masanori; Makita, Yoji
• Is Part Of: Materials today communications. Volume 30(2022)
• Publication Date: 2022-03
• Subjects: Ag -- Antibacterial ability -- OCP -- Bone substitute -- Bioceramics -- Block; Materials science -- Periodicals; 620.11
• DOI: 10.1016/j.mtcomm.2022.103130
• Languages: English
• ISSNs: 2352-4928

Abstract

Abstract: In this study, Ag-substituted octacalcium phosphate (OCP) blocks exhibiting contact antibacterial ability were fabricated from precursor dicalcium dihydrate anhydrate blocks via immersion in both Ag + - and Na + -containing ammonium phosphate weak basic buffer solutions. The diametral tensile strength (DTS) value of the Ag-substituted blocks was ~2.5 MPa, which is sufficient for them to be used as a bone substitute material. Although the Ag contents of the Ag-substituted OCP blocks (0.17 ± 0.01 at%) were much lower than those of Ag-substituted OCP powders (1.72 ± 0.18 at%) prepared using Ag solutions with the same Ag concentration (20 mmol/L), the Ag-substituted OCP blocks exhibited excellent contact antibacterial activities toward various pathogens. In vivo implanting in bone defects evaluations indicated that the biocompatibility of the Ag-substituted OCP blocks was excellent and similar to that of the OCP blocks without Ag. Highlight: Ag substituted OCP block for bone substitute could be fabricated. Ag substituted OCP block was fabricated from precursor block through dissolution-precipitation reactions. Ag substituted OCP block both exhibited excellent antibacterial ability toward to various pathogen and excellent osteoconductivity.