Effect of an inulin-type fructan from Platycodon grandiflorum on the intestinal microbiota in rats exposed to PM2.5. (1st May 2022)

• Record Type: Journal Article
• Authors: Shan, Shan; Xiong, Yi; Guo, Jianguo; Liu, Mengyao; Gao, Xin; Fu, Xinjing; Zeng, Deyong; Song, Chen; Zhang, Yingchun; Cheng, Dayodu; Lu, Weihong
• Is Part Of: Carbohydrate polymers. Volume 283(2022)
• Publication Date: 2022-05-01
• Subjects: Platycodon grandiflorum -- Inulin-type fructan -- PM2.5 -- Intestinal microbiota; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2022.119147
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: In this study, an inulin-type fructan (PGPI-1-a) was isolated from the roots of Platycodon grandiflorum . PGPI-1-a was composed of (2 → 1)-linked β-D-fructofuranose (Fruf) and a terminal α-d -glucopyranose (Glcp) with a molecular weight of 12.1 kDa. PM2.5 exposure has brought a great threat to human health in recent years. Therefore, this study explored the effect of PGPI-1-a on the intestinal microbial community structure of rats exposed to PM2.5 using the animal model of PM2.5 inhalation exposure. The results showed that PGPI-1-a could regulate the intestinal microbiota by partly restoring the perturbed levels of Peptoniphilaceae_[G-2] and Lachnospiraceae_[G-2] caused by PM2.5 exposure. In addition, the relative abundance of Butyrivibrio, a butyric acid-producing genera, significantly increased after PGPI-1-a intervention. These results indicated that PGPI-1-a could improve the imbalance of intestinal microbiota due to PM2.5 exposure to a certain extent. Graphical abstract: Unlabelled Image