Polymeric micelles: Theranostic co-delivery system for poorly water-soluble drugs and contrast agents. (July 2018)

• Record Type: Journal Article
• Authors: Upponi, Jaydev R.; Jerajani, Kaushal; Nagesha, Dattatri K.; Kulkarni, Praveen; Sridhar, Srinivas; Ferris, Craig; Torchilin, Vladimir P.
• Is Part Of: Biomaterials. Volume 170(2018)
• Page Start: 26
• Page End: 36
• Publication Date: 2018-07
• Subjects: Nanoparticles -- Micelles -- Cancer therapy -- Diagnostics -- Drug delivery -- Theranostics; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2018.03.054
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Interest in theranostic agents has continued to grow because of their promise for simultaneous cancer detection and therapy. A platform-based nanosized combination agent suitable for the enhanced diagnosis and treatment of cancer was prepared using polymeric polyethylene glycol-phosphatidylethanolamine-based micelles loaded with both, poorly soluble chemotherapeutic agent paclitaxel and hydrophobic superparamagnetic iron oxide nanoparticles (SPION), a Magnetic Resonance Imaging contrast agent. The co-loaded paclitaxel and SPION did not affect each other's functional properties in vitro . In vivo, the resulting paclitaxel-SPION-co-loaded PEG-PE micelles retained their Magnetic Resonance contrast properties and apoptotic activity in breast and melanoma tumor mouse models. Such theranostic systems are likely to play a significant role in the combined diagnosis and therapy that leads to a more personalized and effective form of treatment.