Cytokine induced killer cells-assisted delivery of chlorin e6 mediated self-assembled gold nanoclusters to tumors for imaging and immuno-photodynamic therapy. (July 2018)

• Record Type: Journal Article
• Authors: Xia, Fangfang; Hou, Wenxiu; Liu, Yanlei; Wang, Wentao; Han, Yu; Yang, Meng; Zhi, Xiao; Li, Chenlu; Qi, Daizong; Li, Tianliang; Martinez de la Fuente, Jesus; Zhang, Chunlei; Song, Jie; Cui, Daxiang
• Is Part Of: Biomaterials. Volume 170(2018)
• Page Start: 1
• Page End: 11
• Publication Date: 2018-07
• Subjects: CIK cells -- Gold nanoclusters -- Chlorin e6 -- Near-infrared fluorescence imaging -- Immunotherapy -- Photodynamic therapy; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2018.03.048
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: The cytotoxicity and unique tumor-tropic properties of cytokine-induced killer (CIK) cells render them promising in the field of cancer immunotherapy and delivery systems. Here, we report a novel and facile approach to assemble gold nanoclusters (GNCs) into stable and monodispersed nanoparticles (NPs) using Chlorin e6 (Ce6) molecules. Notably, the fluorescence intensity of the GNCs-Ce6 NPs was about 4.5 folds stronger than the GNCs counterparts. The as-prepared GNCs-Ce6 NPs were conjugated with CD3 antibody (Ab) and further employed to label CIK cells to create a CIK cell-based drug delivery system (Ce6-GNCs-Ab-CIK). The Ce6-GNCs-Ab-CIK exhibited high tumor-targeting efficiency and excellent therapeutic efficacy toward MGC-803 tumor-bearing mice. Benefiting from the synergistic therapeutic effect between GNCs-Ce6-Ab NPs and CIK cells, the GNCs-Ce6-Ab-CIK strategy may present an ideal cancer theranostic platform for tumor targeted imaging and combination therapy.