Motor representation of rhythmic jaw movements in the amygdala of guinea pigs. (March 2022)

• Record Type: Journal Article
• Authors: Ueno, Yoshio; Higashiyama, Makoto; Haque, Tahsinul; Masuda, Yuji; Katagiri, Ayano; Toyoda, Hiroki; Uzawa, Narikazu; Yoshida, Atsushi; Kato, Takafumi
• Is Part Of: Archives of oral biology. Volume 135(2022)
• Publication Date: 2022-03
• Subjects: Rhythmic jaw movement -- Amygdala -- Electrical microstimulation -- Guinea pig; Mouth -- Periodicals; Mouth -- Diseases -- Periodicals; Dentistry -- Periodicals; Electronic journals; 617.6005
• DOI: 10.1016/j.archoralbio.2022.105362
• Languages: English
• ISSNs: 0003-9969

Abstract

Abstract: Objective: The areas of the amygdala contributing to rhythmic jaw movements and the movement patterns induced remain unknown. Therefore, the present study investigated the areas of the amygdala contributing to rhythmic jaw movements using repetitive electrical microstimulation techniques. Design: Experiments were performed on head-restrained guinea pigs under ketamine-xylazine anesthesia. EMG activities in the masseter and digastric muscles and jaw movements were recorded. Short- and long-train electrical microstimulations of the amygdala were performed and the patterns of jaw movements induced were analyzed quantitatively. Result: The short-train stimulation induced short-latency EMG responses in the masseter and/or digastric muscles. The stimulation sites inducing short-latency EMG responses were distributed within the ventral part of the amygdala, which covered the medial, basal, and cortical nuclei. The long-train stimulation induced tonic jaw opening and two types of rhythmic jaw movements: those with or without lateral jaw shifts, which were characterized by a larger jaw gape and ipsilateral jaw excursion, respectively. Rhythmic jaw movements with lateral jaw shifts were characterized by overlapping masseter and digastric EMG activities. However, rhythmic patterns did not differ between the two types of rhythmic jaw movements. The stimulation sites that induced rhythmic jaw movements were more localized to the cortical nucleus. Conclusions: The present results suggest that the ventral part of the amygdala is involved in the induction of rhythmic jaw movements in guinea pigs. The putative roles of the limbic system in the genesis of functional (e.g., chewing) and non-functional (e.g., bruxism) rhythmic oromotor movements warrant further study. Highlights: Rhythmic jaw movements were induced by stimulation of amygdala in guinea pigs. Two types of rhythmic jaw movements were induced with or without lateral jaw shifts. Effective sites for the two types were distributed in the ventral part of amygdala. The cortical nucleus was related to rhythmic jaw movements with lateral jaw shifts.