Evaluation of memory performance in patients with brain disorders following rTMS treatment. A systematic review. (March 2022)

• Record Type: Journal Article
• Authors: Bonotis, Konstantinos; Anargyros, Konstantinos; Liaskopoulos, Nikolaos; Barlogianni, Anna-Maria
• Is Part Of: Clinical neurophysiology. Volume 135(2022)
• Page Start: 126
• Page End: 153
• Publication Date: 2022-03
• Subjects: Transcranial magnetic stimulation -- rTMS -- Brain disorders -- Memory enhancement -- Memory performance; ACE-III Addenbrooke's Cognitive Examinatio-III -- AD Alzheimer's disease -- ADAS-cog Alzheimer's Disease Assessment Scale–Cognitive Subscale -- ADCS-ADL Alzheimer's Disease Cooperative Study-Activities of Daily Living -- ADCS-PACC Alzheimer's Disease Cooperative Study-Preclinical Alzheimer Cognitive Composite -- AES-C Apathy Evaluation Scale -- aMCI amnestic mild cognitive impairment -- aTMS accelerated transcranial magnetic stimulation -- BDI Beck Depression Inventory -- BVMT Brief Visuospatial Memory Test -- CAMCOG Cambridge Cognition Examination -- CANTAB Cambridge Neuropsychological Test Automated Battery -- CGI-C Clinical Global Impression of Change -- CGI-I Clinical Global Impressions Improvement -- DLPFC dorsolateral prefrontal cortex -- DMN Default mode network -- DSST Digit Symbol Substitution Test -- dTMS deep transcranial magnetic stimulation -- ECT electroconvulsive treatment -- EEG electroencephalography -- fMRI functional magnetic resonance imaging -- HF high frequency -- HFL high frequency left -- HF-rTMS high frequency repetitive transcranial magnetic stimulation -- HVLT Hopkins Verbal Learning Test -- Hz hertz -- IADL Instrumental Activities of Daily Living -- IPL Inferior parietal lobule -- iTBS intermittent theta-burst stimulation -- LF-rTMS low frequency repetitive transcranial magnetic stimulation -- LFR low frequency right -- LMT Letter Memory Test -- LTD long term depression -- LTL lateral temporal lobe -- LTP long term potentiation -- M month(s) -- MC motor cortex -- MDD major depressive disorder -- MIC mild cognitive impairment -- MoCA Montreal Cognitive Assessment -- MMSE Mini Mental State Examination -- 3MS the Modified Mini-Mental State -- MS multiple sclerosis -- MT motor threshold -- N number -- NIBS non-invasive brain stimulation -- OCD obsessive compulsive disorder -- PD Parkinson's disease -- PFC prefrontal cortex -- pSAC parietal somatosensory association cortex -- PTSD post-traumatic stress disorder -- QPS quadripulse stimulation -- RAVLT Rey Auditory Verbal Learning Test -- RBANS Repeatable Battery for the Assessment of Neuropsychological Status -- RBMT Rivermead Behavioural Memory Test -- RCT randomized controlled study -- RMBC Revised Memory and Behaviour Checklist -- RMT resting motor threshold -- rPAS rapid-rate paired associative stimulation -- rTMS repetitive transcranial magnetic stimulation -- s second(s) -- SBST Stanford Binet Test -- SC-BADA Sentence Comprehension-Battery for Analysis of Aphasic Deficits -- TBS theta burst stimulation -- TMS transcranial magnetic stimulation -- TMS-COG transcranial magnetic stimulation with cognitive training -- TPC tempoparietal cortex -- TRD treatment resistant depression -- WAIS Wechsler Adult Intelligence Scale -- WHO-UCLA AVLT World Health Organization-University of California-Los Angeles Auditory Verbal Learning test -- WMS Wechsler Memory Scale; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2021.11.078
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: There is converging evidence for memory improvement in patients with brain disorders following rTMS treatment. A remarkable percentage of positive results was found in patients with mild cognitive impairment and Alzheimer's disease. Future research should consider properly designed treatment protocols including longitudinal follow-up. Abstract: Objective: Repetitive transcranial magnetic stimulation (rTMS) is being used as a non-invasive, non-pharmacological treatment with emerging clinical applications. The objective of this systematic review is to assess the possible rTMS effect on memory performance in patients suffering from central nervous system diseases. Methods: PubMed, Google Scholar, Science Direct and Cochrane Library were searched through April 2021 for rTMS clinical trials in neuropsychiatric conditions, assessing pre-post treatment patients' memory performance with neuropsychological measures. Results: One hundred and four clinical studies were included for evaluation. Overall, a large number of reports were detected with a positive outcome of patients' memory performance, concerning primarily the working memory, whereas there were also inconsistent results. In particular, considerable results were observed in patients with mild cognitive impairment and early stage Alzheimer's disease. Conclusions: Despite the variability of reports and the limited ability to generalize our findings, this review offers further evidence regarding the possible use of rTMS as a memory enhancement tool. Significance: The study provides an updated and broad review in the field and highlights the need for more adequate studies, focusing on treatment procedure characteristics, follow-up and maintenance options of this approach.