Designed Negative Feedback from Transiently Formed Catalytic Nanostructures. (20th September 2019)

• Record Type: Journal Article
• Authors: Afrose, Syed Pavel; Bal, Subhajit; Chatterjee, Ayan; Das, Krishnendu; Das, Dibyendu
• Is Part Of: Angewandte Chemie. Volume 131:Number 44(2019)
• Page Start: 15930
• Page End: 15934
• Publication Date: 2019-09-20
• Subjects: Dissipative Selbstorganisation -- Gele -- Katalyse -- Nanostrukturen -- Systemchemie; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201910280
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Highly dynamic and complex systems of microtubules undergo a substrate‐induced change of conformation that leads to polymerization. Owing to the augmented catalytic potential at the polymerized state, rapid hydrolysis of the substrate is observed, leading to catastrophe, thus realizing the out‐of‐equilibrium state. A simple synthetic mimic of these dynamic natural systems is presented, where similar substrate induced conformational change is observed and a transient helical morphology is accessed. Further, augmented catalytic potential of these helical nanostructures leads to rapid hydrolysis of the substrate providing negative feedback on the stability of the nanostructures and realization of an out‐of‐equilibrium state. This simple system, made from amino acid functionalized lipids, demonstrates a substrate‐induced self‐assembled state, where the fuel‐to‐waste conversion leads to the temporal presence of helical nanostructures. Abstract : Burst‐Katalyse : Eine substratinduzierte transiente helikale Morphologie wurde als selbstorganisierter Zustand erreicht. Rasche Hydrolyse von Substraten resultiert in einer Zerlegung, wodurch die dynamische Instabilität von Mikrotubuli imitiert wird.