Natural products and their derivatives as multifunctional ligands against Alzheimer's disease. Issue 2 (20th August 2019)

• Record Type: Journal Article
• Authors: Patil, Pooja; Thakur, Ashima; Sharma, Abha; Flora, Swaran Jeet Singh
• Other Names: Frenkel Dan guestEditor.
• Is Part Of: Drug development research. Volume 81:Issue 2(2020)
• Page Start: 165
• Page End: 183
• Publication Date: 2019-08-20
• Subjects: Alzheimer's -- alkaloid -- flavonoid -- multitarget ligand; Drug development -- Periodicals; Drugs -- Research -- Periodicals; 615.19
• DOI: 10.1002/ddr.21587
• Languages: English
• ISSNs: 0272-4391

Abstract

Abstract: Alzheimer's disease (AD), a complex neurodegenerative disorder causing multiple cellular changes including impaired cholinergic system, beta‐amyloid (βA) aggregation, tau hyperphosphorylation, metal dyshomeostasis, neuroinflammation, and many other pathways are involved in the pathogenesis of the disease. However, the exact cause of the disease is not known. Natural products such as flavonoids, alkaloids, resveratrol, and curcumin have multifunctional properties, and have drawn the attention of the researchers because these molecules are capable of interacting concurrently with the multiple targets of AD. Therefore, natural products and their derivatives with proven efficacy could be used in the management of the neurodegenerative disorders. This review focuses on the natural product based multitarget directed ligands like tacrine‐coumarin, tacrine‐huperzine A, harmine‐isoxazoline, berberine‐thiophenyl, galantamine‐indole, pyridoxine‐resveratrol, donepezil‐curcumin and their mode of action.