Inside Cover: Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase (Angew. Chem. Int. Ed. 3/2017). Issue 3 (22nd December 2016)

• Record Type: Journal Article
• Authors: O'Dell, William B.; Agarwal, Pratul K.; Meilleur, Flora
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 3(2017)
• Page Start: 658
• Page End: 658
• Publication Date: 2016-12-22
• Subjects: copper -- oxidoreductases -- oxygen activation -- polysaccharide monooxygenases -- protein structures; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201611987
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Oxidative cleavage of glycosidic bonds allows lytic polysaccharide monooxygenases (LPMOs) to break polysaccharide chains. This activity enhances the enzymatic hydrolysis of recalcitrant carbohydrate biomass, such as cellulose or chitin. In their Communication on page 767 ff., F. Meilleur and co‐workers provide a structural description of molecular‐oxygen activation by a fungal LPMO at the mononuclear copper active site as revealed by X‐ray and neutron crystallography and DFT calculations. Credit: J. Hemman.