Adaptive Hydrogels Based on Nanozyme with Dual‐Enhanced Triple Enzyme‐Like Activities for Wound Disinfection and Mimicking Antioxidant Defense System. Issue 2 (23rd November 2021)

• Record Type: Journal Article
• Authors: Li, Yang; Fu, Rongzhan; Duan, Zhiguang; Zhu, Chenhui; Fan, Daidi
• Is Part Of: Advanced healthcare materials. Volume 11:Issue 2(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-23
• Subjects: bacterial infections -- infected wound healing -- multifunctional hydrogels -- oxidative stress -- triple enzyme‐like activities; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202101849
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Bacterial infection and oxidative stress are two critical problems for chronic infected wound healing. Here, molybdenum disulfide nanosheets (MoS2 NSs) with triple enzyme‐like activities are loaded onto carbon nanotubes (CNTs) and incorporated into multifunctional hydrogels aiming to eradicate bacteria and eliminate free radicals. The nanozyme activities of MoS2 are significantly enhanced through CNTs and near‐infrared irradiation. The hydrogel exhibits significant antibacterial performance attributed to the peroxidase‐like activity (catalyzing hydrogen peroxide (H2 O2 ) into hydroxyl free radicals (OH)) under acidic conditions, glutathione loss, and photothermal therapy. Additionally, the nanozyme can mimic the superoxide‐like activity to transform the superoxide radicals (O2 − ) into H2 O2 and oxygen (O2 ), then H2 O2 is further depleted into O2 via the catalase‐like activity, benefitting from which and OH scavenging ability, the hydrogel shows excellent scavenging free radical ability in neutral environment and provides abundant O2 for wound healing. The multifunctional hydrogel, crosslinked by dynamic boron ester bonds, exhibits adhesiveness, self‐healing, and shape‐adaptivity, which can fill the cavity of irregular wounds and promote the nanozyme to play the role with maximum efficiency. The hydrogels notably accelerate the skin reconstruction through killing bacteria, clearing ROS, promoting collagen deposition and angiogenesis. Abstract : Infected wound healing is notably accelerated through an adaptive hydrogel, which presents excellent anti‐bacterial abilities and anti‐oxidant properties via peroxidase‐, catalase‐, and superoxide dismutase‐like activities. Meanwhile, abundant oxygen (O2 ) is supplied for the wound. The triple enzyme‐like activities of MoS2 are greatly enhanced through carbon nanotubes (CNTs) and nearinfrared (NIR) irradiation.