A summary of the diagnostic and prognostic value of hemocytometry markers in COVID-19 patients. (17th August 2020)

• Record Type: Journal Article
• Authors: Khartabil, T. A.; Russcher, H.; van der Ven, Ajam; de Rijke, Y. B.
• Is Part Of: Critical reviews in clinical laboratory sciences. Volume 57:Number 6(2020)
• Page Start: 415
• Page End: 431
• Publication Date: 2020-08-17
• Subjects: COVID-19 -- hemocytometry -- white blood cells -- red blood cells -- platelets; Diagnosis, laboratory -- Periodicals; Medicine, Clinical -- Periodicals; 616.07
• DOI: 10.1080/10408363.2020.1774736
• Languages: English
• ISSNs: 1040-8363

Abstract

Abstract: Many studies have reported hemocytometric changes in COVID-19 infection at admission and during the course of disease, but an overview is lacking. We provide a summary of the literature of hemocytometric changes and evaluate whether these changes may assist clinicians in diagnosing and predicting disease progression of COVID-19. Eighty-three out of 250 articles from December 2019 to 20 May 2020 were included from the databases, PubMed, Web of Science Core Collection, Embase, Cochrane and MedRxiv. Our review of the literature indicates that lymphopenia and an elevated neutrophil/lymphocyte ratio are the most consistent abnormal hemocytometric findings and that these alterations may augment in the course of time, especially in those with severe disease.