ALK/ROS1 rearrangements: A real hallmark for thromboembolic events in cancer patients?. Issue 194 (October 2020)

• Record Type: Journal Article
• Authors: Nichetti, Federico; Lo Russo, Giuseppe; Prelaj, Arsela; Provenzano, Leonardo; de Braud, Filippo; Cabiddu, Mary; Garassino, Marina Chiara; Petrelli, Fausto
• Is Part Of: Thrombosis research. Issue 194(2020)
• Page Start: 176
• Page End: 177
• Publication Date: 2020-10
• Subjects: Non-Small-Cell Lung Cancer -- Thromboembolic events -- Thrombosis -- ALK -- ROS-1 -- Tyrosine kinase inhibitors; Thrombosis -- Periodicals; 616.135
• DOI: 10.1016/j.thromres.2020.06.041
• Languages: English
• ISSNs: 0049-3848

Abstract

Highlights: ALK/ROS1-rearranged NSCLC NSCLC patients seem to be at increased risk of VTEs However, this evidence comes from retrospective, heterogeneous studies, and the impact of anticancer treatments on this risk in poorly investigated We performed a meta-analysis of prospective data to assess the risk of VTEs in ALK/ROS1-rearranged NSCLC patients We showed that TKIs targeting ALK/ROS1-rearranged NSCLC did not significantly increase VTEs risk compared to platinum-based CT Our data support the idea that VTE risk in ALK/ROS1-rearranged NSCLC patients is related to the molecular driver irrespectively of the treatment