Multivalent Noncovalent Interfacing and Cross‐Linking of Supramolecular Tubes. Issue 5 (14th December 2021)

• Record Type: Journal Article
• Authors: Xiu, Fangyuan; Knežević, Anamarija; Kwangmettatam, Supaporn; Di Iorio, Daniele; Huskens, Jurriaan; Kudernac, Tibor
• Is Part Of: Advanced materials. Volume 34:Issue 5(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-14
• Subjects: chiral tubes -- cross‐linking -- streptavidin–biotin interactions -- supramolecular networks -- supramolecular polymers -- surface binding; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202105926
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Natural supramolecular filaments have the ability to cross‐link with each other and to interface with the cellular membrane via biomolecular noncovalent interactions. This behavior allows them to form complex networks within as well as outside the cell, i.e., the cytoskeleton and the extracellular matrix, respectively. The potential of artificial supramolecular polymers to interact through specific noncovalent interactions has so far only seen limited exploration due to the dynamic nature of supramolecular interactions. Here, a system of synthetic supramolecular tubes that cross‐link forming supramolecular networks, and at the same time bind to biomimetic surfaces by the aid of noncovalent streptavidin–biotin linkages, is demonstrated. The architecture of the networks can be engineered by controlling the density of the biotin moiety at the exterior of the tubes as well as by the concentration of the streptavidin. The presented strategy provides a pathway for designing adjustable artificial supramolecular superstructures, which can potentially yield more complex biomimetic adaptive materials. Abstract : A hierarchical synthetic supramolecular network is formed and interfaced to biomimetic surfaces using purely noncovalent interactions. Supramolecular synthetic copolymer bearing biotin linking group forms supramolecular networks upon addition of streptavidin, and can bind to streptavidin‐modified surfaces. The architectures of these networks can be tuned by changing the biotin ratio in supramolecular copolymer and the concentration of streptavidin.