CD8 T‐cell‐mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer. (8th August 2021)

• Record Type: Journal Article
• Authors: Hardwick, Marc; Nolan, Luke; Nicoll, James A. R.; Jogai, Sanjay; Arriola, Edurne; Joseph‐Pietras, Debora; Norman, Jeanette; Ottensmeier, Christian H. H.; Galea, Ian
• Is Part Of: Neuropathology & applied neurobiology. Volume 48:Number 2(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-08-08
• Subjects: CD8 T cells -- cerebellitis -- CTLA‐4 inhibitor -- immune checkpoint inhibitors -- ipilimumab -- paraneoplastic cerebellar degeneration; Nervous system -- Diseases -- Pathology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/nan.12755
• Languages: English
• ISSNs: 0305-1846

Abstract

Abstract : We report a rapidly progressive and fatal CD8 T‐cell‐mediated cerebellitis after ipilimumab (cytotoxic T‐lymphocyte‐associated protein 4 inhibitor) for small cell lung cancer. Clinical features and histopathology were consistent with an accelerated form of paraneoplastic cerebellar degeneration. A patchy CD8 T‐cell infiltrate spatially corresponded to areas of Purkinje cell loss, with occasional CD8 polarisation towards Purkinje cells. CD20‐positive B cells were sparse. CD8 T‐cell‐mediated cerebellitis after immune checkpoint inhibitor treatment may recapitulate the early stages of paraneoplastic cerebellar degeneration.