Fast update of undetected Mycobacterium chimaera infections to reveal unsuspected cases. Issue 4 (December 2018)

• Record Type: Journal Article
• Authors: Acosta, F.; Pérez-Lago, L.; Ruiz Serrano, M.J.; Marín, M.; Kohl, T.A.; Lozano, N.; Niemann, S.; Valerio, M.; Olmedo, M.; Pérez-Granda, M.J.; Pérez Pérez, M.R.; Bouza, E.; Muñoz, P.; García de Viedma, D.
• Is Part Of: Journal of hospital infection. Volume 100:Issue 4(2018)
• Page Start: 451
• Page End: 455
• Publication Date: 2018-12
• Subjects: Heater–cooler units -- Mycobacterium chimaera -- Cardiac surgery -- Whole-genome sequencing; Cross infection -- Periodicals; Cross infection -- Prevention -- Periodicals; Nosocomial infections -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Cross Infection -- Periodicals; Cross Infection -- prevention & control -- Periodicals; Infection Control -- Periodicals; Electronic journals; 614.44
• DOI: 10.1016/j.jhin.2018.08.018
• Languages: English
• ISSNs: 0195-6701

Abstract

Summary: Mycobacterium chimaera is involved in a worldwide alert due to contaminated heater–cooler units. A real-time polymerase chain reaction (RT-PCR)-based procedure was implemented to survey undetected cases of M. chimaera infection. PCR was negative in the 59 prosthetic heart valves from patients with PCR-16SrRNA-negative infective endocarditis. PCR identified M. chimaera in one of 15 clinically significant retrospective Mycobacterium avium–Mycobacterium intracellulare complex isolates, which corresponded to a patient who had undergone heart valve replacement in a different institution. Whole-genome sequencing demonstrated that he was the first case in Spain with involvement of the strain responsible for the global outbreak. These results highlight the relevance of retrospective tracking for undetected M. chimaera infections.