Oral iron supplementation in patients with chronic kidney disease: Can it be harmful to the gut microbiota?. (12th May 2021)

• Record Type: Journal Article
• Authors: Ribeiro, Marcia; Fonseca, Larissa; Anjos, Juliana S.; Capo‐chichi, Jean C. C.; Borges, Natália A.; Burrowes, Jerrilynn; Mafra, Denise
• Is Part Of: Nutrition in clinical practice. Volume 37:Number 1(2022)
• Page Start: 81
• Page End: 93
• Publication Date: 2021-05-12
• Subjects: chronic kidney disease -- iron -- iron deficiency anemia -- microbiota; Nutrition -- Periodicals; Diet therapy -- Periodicals; Artificial feeding -- Periodicals; 615.854
• DOI: 10.1002/ncp.10662
• Languages: English
• ISSNs: 0884-5336

Abstract

Abstract: Patients with chronic kidney disease (CKD) have several pathophysiological alterations, including anemia, one of the first changes in CKD patients. More recently, researchers have observed that the intestinal microbiota alterations are also another complication in these patients. The most common treatment for anemia is oral (mainly ferrous sulfate) or intravenous iron supplementation. Despite being a necessary treatment, recent studies have reported that supplementation with oral iron may increase its availability in the intestine, leading to disturbance in the gut microbiota and also to oxidative stress in the enterocytes, which may change the permeability and the microbiota profile. Although it is a therapy routinely used in patients with CKD, supplementation with oral iron on the gut microbiota has been rarely studied in these patients. Thus, this review will discuss the relationship between iron and the gut microbiota and the possible effects of oral iron supplementation on gut microbiota in patients with CKD.