Pituitary corticotroph tumour with adrenocortical cells: A distinct clinicopathologic entity with unique morphology and methylation profile. (9th August 2021)

• Record Type: Journal Article
• Authors: Hickman, Richard A.; Gionco, John T.; Faust, Phyllis L.; Miller, Michael L.; Bruce, Jeffrey; Page‐Wilson, Gabrielle; Rosenblum, Marc K.; Asa, Sylvia L.
• Is Part Of: Neuropathology & applied neurobiology. Volume 48:Number 2(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-08-09
• Subjects: adrenocortical cells -- choristoma -- corticotroph tumour; Nervous system -- Diseases -- Pathology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/nan.12754
• Languages: English
• ISSNs: 0305-1846

Abstract

Abstract : We describe a rare TPIT‐positive corticotroph PitNET that is admixed with SF1‐positive adrenocortical cells. This dimorphous population of cells showed no colocalisation between TPIT and SF1 by immunofluorescence, and an adrenocortical choristoma was favoured. Methylation array analysis revealed a novel methylation profile in relation to other pituitary neoplasms.