Case Series: Cariprazine for treatment of methamphetamine use disorder. Issue 1 (29th October 2021)

• Record Type: Journal Article
• Authors: Truong, Thanh Thuy; Li, Benjamin
• Is Part Of: American journal on addictions. Volume 31:Issue 1(2022)
• Page Start: 85
• Page End: 88
• Publication Date: 2021-10-29
• Subjects: Substance abuse -- Periodicals; Substance abuse -- Treatment -- Periodicals; 616.86005
• DOI: 10.1111/ajad.13241
• Languages: English
• ISSNs: 1055-0496

Abstract

Abstract: Background and Objectives: Methamphetamine use is a major source of morbidity and mortality but has no reliably effective interventions. We identified cariprazine as an option for treatment of methamphetamine use disorder (MUD) and present two cases. Methods: Two patients with MUD and psychotic disorders were treated with cariprazine. Abstinence and cravings were assessed using urine drug screens and the Brief Substance Craving Scale, respectively. Results: Both patients reported global functional improvement, reduction in methamphetamine cravings and use with cariprazine, confirmed with negative urine drug screens. Conclusions and Scientific Significance: Cariprazine's unique pharmacodynamic profile conveys potential efficacy for MUD. It would be a novel treatment that targets multiple psychiatric symptoms seen in MUD.