A Chiral Copper Catalyzed Site‐Selective O‐Alkylation of Carbohydrates. Issue 3 (29th November 2021)

• Record Type: Journal Article
• Authors: Ren, Bo; Wang, Jiaxi; Zhang, Mengyao; Chen, Yue; Zhao, Wei
• Is Part Of: Advanced synthesis & catalysis. Volume 364:Issue 3(2022)
• Page Start: 665
• Page End: 670
• Publication Date: 2021-11-29
• Subjects: Copper -- Alkylation -- Trans-diols -- Chiral ligands -- Carbohydrates; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202101121
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Highly regioselective alkylation of sugar hydroxyl groups has always been an important challenge in carbohydrate chemistry, especially for the selective alkylation of trans diols, there is no direct and efficient catalytic method so far. A chiral copper catalyzed universal highly site‐selective alkylation of trans‐diols method is realized. This reaction is performed under mild conditions and has broad substrate scope. The selectivity of the reactions can be controlled by adjusting the copper reagents and the chiral ligands. This method was also applied to the site‐selective modification of drugs and natural products. Abstract :