Effects of the environmental endocrine disrupting compound benzo[a]pyrene on thyroidal status of abu mullet (Liza abu) during short-term exposure. (2018)

• Record Type: Journal Article
• Authors: Movahedinia, Abdolali; Salamat, Negin; Kheradmand, Parvin
• Is Part Of: Toxicology reports. Volume 5(2018)
• Page Start: 377
• Page End: 382
• Publication Date: 2018
• Subjects: BaP benzo[a]pyrene -- EDC endocrine disrupting chemical -- PAH polycyclic aromatic hydrocarbon -- PCB polychlorinated biphenyl -- ROPME Regional Organization for the Protection of the Marine Environment -- RSA ROPME sea area -- T3 triiodothyronine (3, 5, 3-triiodo-l-thyroinine) -- T4 thyroxine (3, 5, 3, 5-tetraiodo-l-thyronine) -- TSH thyroid-stimulating hormone; Polycyclic aromatic hydrocarbon -- Fish -- Triiodothyronine -- Thyroxine; Toxicology -- Periodicals; Clinical toxicology -- Periodicals; Drug-Related Side Effects and Adverse Reactions; Hazardous Substances; Poisoning; Toxicology; Electronic journals; Periodicals; Periodicals; 571.9505
• DOI: 10.1016/j.toxrep.2018.02.018
• Languages: English
• ISSNs: 2214-7500

Abstract

Highlights: The half-life of BaP is 3–4 days and then it metabolized in the liver. BaP concentration in the muscle of treated fish reached a maximum level after 4 days. Exposure of fish to BaP resulted in a decrease in T3 and T4 plasma levels up to day 4. Exposure of fish to BaP resulted in an increase in TSH plasma level up to day 4. Abstract: Benzo[a]Pyrene (BaP) is a ubiquitous polycyclic aromatic hydrocarbon (PAH) that has been shown to disrupt the metabolism of thyroid hormone. Then, the present investigation aimed to study the effects of BaP on thyroid function in Liza abu . Fish were injected with 2, 10 and 25 mg/kg-bw of BaP. Samples were taken from blood, thyroid and muscle tissues at days 1, 2, 4, 7, and 14. Blood was evaluated for changes in the plasma levels of TSH, T3 and T4. Also, BaP bioaccumulation in the fish muscle was measured. Thyroid tissues were processed for routine histology. BaP concentration in the muscle of treated fish reached a maximum level after 4 days. Exposure of fish to BaP resulted in a significant decrease in T3 and T4 plasma level and increase in TSH concentration up to day 4. Also some pathological alterations were observed in BaP-exposed fish such as hemorrhage and increased number of large follicles with squamous epithelium. In conclusion, according to the results of the present investigation, short term exposure to sublethal concentrations of BaP significantly affected thyroid function in fish. The results revealed BaP ability to alter thyroid function.