Eco‐friendly PCL@CDs biomaterials via phytic acid, CDs‐cocatalyzed polymerization for rifapentin delivery. Issue 16 (9th December 2021)

• Record Type: Journal Article
• Authors: Wang, Guoyu; Ren, Huifang; Chen, Qiuyang; Zhou, Mingchen; Xie, Fei; Yan, Manqing; Wang, Qiyang; Bi, Hong
• Is Part Of: Journal of applied polymer science. Volume 139:Issue 16(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-09
• Subjects: biocompatibility -- catalysts -- composites -- drug delivery systems -- ring‐opening polymerization; Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.51984
• Languages: English
• ISSNs: 0021-8995

Abstract

Abstract: Although biodegradable and biocompatible polymers have great advantages as a research hotspot, the single polymer does not satisfy multifunctional needs in biomaterials application. Herein, carbon dots (CDs) with strong fluorescence and good hydrophilicity were prepared through effective microwave method from citric acid and ethanediamine. Then green PCL@CDs biomaterials were fabricated by the ring‐opening polymerization (ROP) of ε‐caprolactone (ε‐CL) via green phytic acid and active CDs as catalysts. Importantly, the as‐obtained PCL@CDs hybrids with good biocompatibility, adjustable hydrophilicity and good fluorescence could load antituberculosis rifapentine (RFT) by the method of oil/water emulsion solvent evaporation. Also, the morphology, RFT loading and release activity of PCL@CDs@RFT microspheres were deeply investigated. The results showed that the maximum drug loading and encapsulation rate of the prepared PCL@CDs@RFT microspheres were 7.8% and 81%, respectively. Therefore, the binary material can be used as a kind of potential fluorescent labeling biomaterial for drug delivery. Abstract : Synthesis illustration of CDs, PCL@CDs and PCL@CDs@RFT microspheres.