PEG-based nanocomposite hydrogel: Thermo-responsive sol-gel transition and degradation behavior controlled by the LA/GA ratio of PLGA-PEG-PLGA. (January 2018)

• Record Type: Journal Article
• Authors: Kitagawa, Midori; Maeda, Tomoki; Hotta, Atsushi
• Is Part Of: Polymer degradation and stability. Volume 147(2018)
• Page Start: 222
• Page End: 228
• Publication Date: 2018-01
• Subjects: PLGA-PEG-PLGA -- Nanocomposite -- Thermo-responsive hydrogel -- Biodegradable; Polymers -- Deterioration -- Periodicals; Stabilizing agents -- Periodicals; Polymères -- Dégradation -- Périodiques; Stabilisants -- Périodiques; 668.9
• DOI: 10.1016/j.polymdegradstab.2017.11.024
• Languages: English
• ISSNs: 0141-3910

Abstract

Abstract: The sol-gel transition behavior and the degradation behavior of the nanocomposites consisting of laponite clay nanoparticles and poly(d, l -lactide -co- glycolide)- b -poly(ethylene glycol)- b -poly(d, l -lactide -co- glycolide) (PLGA-PEG-PLGA) triblock copolymers (laponite/PLGA-PEG-PLGA nanocomposites) were studied changing the LA/GA ratios of the PLGA blocks in the PLGA-PEG-PLGA. The thermo-responsive sol-gel transition at the physiological temperature (25–37 °C) was observed using the PLGA-PEG-PLGA with a high PEG/PLGA ratio of ∼0.8 regardless of the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). The decomposition rates of the laponite/PLGA-PEG-PLGA nanocomposites at 37 °C were regulated by adjusting the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). Specifically, ∼45% of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratio of 1.1, while ∼30% of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratios of 4.0 and 8.8. Highlights: PLGA-PEG-PLGA hydrogel with a high PEG/PLGA ratio (∼0.8) was made. Thermo-responsive sol-gel transition at physiological temperature was realized. Decomposition of laponite/PLGA-PEG-PLGA was regulated by LA/GA ratios. Faster decomposition was observed for lower LA/GA-ratio nanocomposites.