Switching biologics in children with psoriasis: Results from the BiPe cohort. Issue 1 (9th December 2021)

• Record Type: Journal Article
• Authors: Phan, Céline; Beauchet, Alain; Reguiai, Ziad; Severino‐Freire, Maëlla; Mazereeuw‐Hautier, Juliette; Bursztejn, Anne‐Claire; Barbarot, Sébastien; Hadj‐Rabia, Smaïl; Girard, Céline; Phan, Alice; Lacour, Jean‐Philippe; Lasek, Audrey; Abasq, Claire; Brenaut, Emilie; Perrussel, Marc; Droitcourt, Catherine; Mallet, Stéphanie; Piram, Maryam; Fougerousse, Anne‐Claire; Barthélémy, Hugues; Balguérie, Xavier; Mahé, Emmanuel
• Is Part Of: Pediatric dermatology. Volume 39:Issue 1(2022)
• Page Start: 35
• Page End: 41
• Publication Date: 2021-12-09
• Subjects: adalimumab -- adolescents -- biologics -- children -- etanercept -- psoriasis -- ustekinumab; Pediatric dermatology -- Periodicals; Children -- Diseases -- Periodicals; 618.925
• DOI: 10.1111/pde.14845
• Languages: English
• ISSNs: 0736-8046

Abstract

Abstract: Background: There is currently little information on switching biologics in pediatric psoriasis. Objective: To evaluate the real‐world clinical practice and safety of switching biologics in the "Biological Treatments for Pediatric Psoriasis" (BiPe) cohort. Methods: Data for all 134 patients included in the BiPe cohort were analyzed. A further evaluation of the subpopulation of patients who switched from a first‐line biologic to a second‐line biologic was then conducted. Drug survival rates were also compared between biologics given as first‐line or second‐line agents. Results: Overall, 29 patients (female: 55%; mean age: 16.6 ± 3.0 years) switched between two biologics. Etanercept (ETN) was the first‐line biologic used in 23 patients: 16 (69.6%) switched to adalimumab (ADA) and seven (30.4%) to ustekinumab (UST). Six patients received first‐line ADA and switched to UST. Loss of efficacy (62.1%), primary inefficacy (20.7%), and parental choice (6.9%) were the main reasons for switching biologics. One (3.4%) of the switches was performed because of adverse events or intolerance. For UST and ADA, the 18‐month drug survival rate did not differ according to whether the agent was given as a first‐line or second‐line biologic (UST: P = .24; ADA: P = .68). No significant differences in drug survival rates were observed between the three different switches (ADA to UST, ETN to ADA, and ETN to UST). Conclusion: Our study provided key insights into the real‐life clinical practice of switching biologics in pediatric psoriasis patients. However, more information and guidance on switching biologics in pediatric psoriasis are needed to improve real‐life practice and outcomes.