T‐cell lymphoma, B‐cell lymphoma, and myelodysplastic syndrome harboring common mutations: Trilineage tumorigenesis from a common founder clone. Issue 1 (3rd December 2021)

• Record Type: Journal Article
• Authors: Yoshihara, Kyoko; Nannya, Yasuhito; Matsuda, Ikuo; Samori, Mami; Utsunomiya, Nobuto; Okada, Masaya; Hirota, Seiichi; Ogawa, Seishi; Yoshihara, Satoshi
• Is Part Of: EJHaem. Volume 3:Issue 1(2022)
• Page Start: 211
• Page End: 214
• Publication Date: 2021-12-03
• Subjects: angioimmunoblastic T‐cell lymphoma -- common mutations -- diffuse large B‐cell lymphoma -- founder clone -- multilineage tumorigenesis -- myelodysplastic syndrome; Hematology -- Periodicals; 616.15
• DOI: 10.1002/jha2.354
• Languages: English
• ISSNs: 2688-6146

Abstract

Abstract: A 64‐year‐old man with angioimmunoblastic T‐cell lymphoma (AITL) subsequently developed diffuse large B‐cell lymphoma (DLBCL) and myelodysplastic syndrome (MDS). Genomic profiling of AITL, DLBCL, and MDS samples revealed that the tumor cells from all samples shared common mutations in TET2 and DNMT3A . In addition, the IDH2 mutation was observed in AITL, and TP53 mutation was observed in DLBCL and MDS. These findings illustrate the clonal relationship between AITL and DLBCL in addition to AITL and MDS, with the latter being increasingly reported. The present findings strongly support the theory of multistep and multilineage tumorigenesis from a common founder clone.