Modulation of the NOD-like receptors NOD1 and NOD2: A chemist's perspective. Issue 10 (15th May 2019)

• Record Type: Journal Article
• Authors: D'Ambrosio, Elizabeth A.; Drake, Walter R.; Mashayekh, Siavash; Ukaegbu, Ophelia I.; Brown, Ashley R.; Grimes, Catherine L.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 29:Issue 10(2019)
• Page Start: 1153
• Page End: 1161
• Publication Date: 2019-05-15
• Subjects: Innate immune receptors -- Leucine rich repeat -- Peptidoglycan -- Nod-like-receptors (NLRs) -- Modulation of innate immune signaling -- Post-translational modification (PTM) -- Muramyl dipeptides; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2019.03.010
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: The innate immune system is the body's first defense against invading microorganisms, relying on the recognition of bacterial-derived small molecules by host protein receptors. This recognition event and downstream immune response rely heavily on the specific chemical features of both the innate immune receptors and their bacterial derived ligands. This review presents a chemist's perspective on some of the most crucial and complex components of two receptors (NOD1 and NOD2): starting from the structural and chemical characteristics of bacterial-derived small molecules, to the specific proposed models of molecular recognition of these molecules by immune receptors, to the subsequent post-translational modifications that ultimately dictate downstream immune signaling. Recent advances in the field are discussed, as well as the potential for the development of targeted therapeutics.