Design, synthesis, biological evaluation, and molecular docking studies of some novel N, N‐dimethylaminopropoxy‐substituted aurones. (21st October 2021)

• Record Type: Journal Article
• Authors: Kumar, Gourav; Saroha, Bhavna; Kumar, Ramesh; Kumari, Meena; Dalal, Sunita; Kumar, Suresh
• Is Part Of: Journal of heterocyclic chemistry. Volume 59:Number 2(2022)
• Page Start: 297
• Page End: 308
• Publication Date: 2021-10-21
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.4384
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract: In continuation of our ongoing research on the discovery of novel and potentially bioactive aurones, we have designed and synthesized some novel N, N ‐dimethylaminopropoxy‐substituted pyrazole‐based aurones 10 (a‐l ). These pyrazole‐benzofuranone hybrid compounds were characterized by using their IR, 1 H‐NMR, 13 C‐NMR, and mass spectrometry data. Compound 10c was used as a model to further explicate the structure of tilted compounds by means of 1 H‐ 1 H COSY, 1 H‐ 13 C HMQC, 1 H‐ 13 C HMBC, 1 H‐ 1 H TOCSY, 1 H‐ 1 H NOSEY, DEPT‐45°, DEPT‐90°, and DEPT‐135° NMR spectra. The comparative molecular docking study of N, N ‐dimethylaminopropoxy‐substituted pyrazole‐based aurones and standard drugs (Ampicillin and Chloramphenicol) against Bacillus subtilis (PDB: 6tzp) active site was performed to determine the binding interactions, binding energy, and orientation of the molecules at the active site of the target protein. Out of these synthesized compounds, five best analogs (10b, 10f, 10h, 10k, and 10l ) of docking results were also evaluated for their in vitro antibacterial potential against Bacillus subtilis to validate the docking results. Abstract :