Biomembrane‐Functionalized Micromotors: Biocompatible Active Devices for Diverse Biomedical Applications. Issue 5 (18th December 2021)

• Record Type: Journal Article
• Authors: Zhang, Fangyu; Mundaca‐Uribe, Rodolfo; Askarinam, Nelly; Li, Zhengxing; Gao, Weiwei; Zhang, Liangfang; Wang, Joseph
• Is Part Of: Advanced materials. Volume 34:Issue 5(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-18
• Subjects: cell membranes -- detoxification -- drug delivery -- immunotherapy -- micromotors -- phototherapy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202107177
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: There has been considerable interest in developing synthetic micromotors with biofunctional, versatile, and adaptive capabilities for biomedical applications. In this perspective, cell membrane‐functionalized micromotors emerge as an attractive platform. This new class of micromotors demonstrates enhanced propulsion and compelling performance in complex biological environments, making them suitable for various in vivo applications, including drug delivery, detoxification, immune modulation, and phototherapy. This article reviews various proof‐of‐concept studies based on different micromotor designs and cell membrane coatings in these areas. The review focuses on the motor structure and performance relationship and highlights how cell membrane functionalization overcomes the obstacles faced by traditional synthetic micromotors while imparting them with unique capabilities. Overall, the cell membrane‐functionalized micromotors are expected to advance micromotor research and facilitate its translation towards practical uses. Abstract : This review discusses the preparation, unique capabilities, and advantages of biomimetic micromotors, leveraging the attractive properties of cell membrane‐derived natural biomaterials and the dynamic movement of synthetic micromotors. Such cell membrane‐functional micromotors enable important biomedical operations across a wide range of applications, including drug delivery, decontamination, immunotherapy, and phototherapy.