Suicide Risk in Rheumatoid Arthritis Patients is Associated With Suboptimal Vitamin D Levels. Issue 3 (16th April 2022)

• Record Type: Journal Article
• Authors: Calderón Espinoza, Ivette; Chavarria-Avila, Efrain; Pizano-Martinez, Oscar; Martínez-García, Erika Aurora; Armendariz-Borunda, Juan; Marquez-Aguirre, Ana Laura; Llamas-García, Arcelia; Corona-Sánchez, Esther Guadalupe; Toriz González, Guillermo; Vazquez-Del Mercado, Monica
• Is Part Of: Journal of clinical rheumatology. Volume 28:Issue 3(2022)
• Page Start: 137
• Page End: 142
• Publication Date: 2022-04-16
• Subjects: rheumatoid arthritis -- suicide ideation -- suicide intention -- suicide risk -- vitamin D; Rheumatism -- Periodicals; Rheumatology -- Periodicals; Musculoskeletal system -- Diseases -- Periodicals; Musculoskeletal Diseases -- Periodicals; Rheumatic Diseases -- Periodicals; Rhumatisme -- Périodiques; Rhumatologie -- Périodiques; Appareil locomoteur -- Maladies -- Périodiques; Musculoskeletal system -- Diseases; Rheumatism; Rheumatology; Periodicals; 616.723005
• DOI: 10.1097/RHU.0000000000001823
• Languages: English
• ISSNs: 1076-1608

Abstract

Abstract : Background/Objective: Rheumatoid arthritis (RA) patients might experience anxiety and depressive symptoms. Deficient vitamin D levels may be a trigger for these conditions. The aim of this study was to determine the frequency of depression, anxiety symptoms, and suicidal risk or ideation in patients with RA associated with vitamin D serum levels. Methods: In this cross-sectional study, we recruited RA patients older than 18 years, classified into 3 groups according to serum vitamin D levels: sufficient, ≥30 ng/mL; insufficient, 20–29 ng/mL; and deficient, <20 ng/mL. Based on the self-reported Plutchik and the Hospital Anxiety and Depression Scale, we evaluated the association of suicidal risk, depression, and anxiety with the vitamin D levels in RA and the Rheumatoid Arthritis Quality-of-Life Questionnaire. Results: We studied 72 patients with RA between January and October 2019. We found an inverse correlation between Plutchik score and suicidal risk with inadequate vitamin D levels, but not with the Hospital Anxiety and Depression Scale. Suicidal ideation was associated with a higher score on the Rheumatoid Arthritis Quality-of-Life Questionnaire. Conclusions: Despite the high prevalence of depressive and anxiety symptoms in RA patients, a Plutchik low correlation coefficient with inadequate serum levels of vitamin D was found. However, in the analysis of covariance, we were able to find that vitamin D levels remain associated with a reduction of suicide ideation. Further studies are needed to identify a risk profile for early psychological interventions to improve the quality of life in RA patients.