Using inpatient electronic medical records to study influenza for pandemic preparedness. Issue 2 (25th October 2021)

• Record Type: Journal Article
• Authors: Fuller, Candace C.; Cosgrove, Austin; Sands, Kenneth; Miller, Karla M.; Poland, Russell E.; Rosen, Edward; Sorbello, Alfred; Francis, Henry; Orr, Robert; Dutcher, Sarah K.; Measer, Gregory T.; Cocoros, Noelle M.
• Is Part Of: Influenza and other respiratory viruses. Volume 16:Issue 2(2022)
• Page Start: 265
• Page End: 275
• Publication Date: 2021-10-25
• Subjects: electronic medical records -- influenza hospitalizations -- public health surveillance; Influenza -- Periodicals; Respiratory infections -- Periodicals; Virus diseases -- Periodicals; Influenza, Human -- Periodicals; Respiratory Tract Diseases -- Periodicals; Virus Diseases -- Periodicals; Grippe -- Périodiques; Appareil respiratoire -- Infections -- Périodiques; Maladies à virus -- Périodiques; 616.203
• DOI: 10.1111/irv.12921
• Languages: English
• ISSNs: 1750-2640

Abstract

Abstract: Background: We assessed the ability to identify key data relevant to influenza and other respiratory virus surveillance in a large‐scale US‐based hospital electronic medical record (EMR) dataset using seasonal influenza as a use case. We describe characteristics and outcomes of hospitalized influenza cases across three seasons. Methods: We identified patients with an influenza diagnosis between March 2017 and March 2020 in 140 US hospitals as part of the US FDA's Sentinel System. We calculated descriptive statistics on the presence of high‐risk conditions, influenza antiviral administrations, and severity endpoints. Results: Among 5.1 million hospitalizations, we identified 29, 520 hospitalizations with an influenza diagnosis; 64% were treated with an influenza antiviral within 2 days of admission, and 25% were treated >2 days after admission. Patients treated >2 days after admission had more comorbidities than patients treated within 2 days of admission. Patients never treated during hospitalization had more documentation of cardiovascular and other diseases than treated patients. We observed more severe endpoints in patients never treated (death = 3%, mechanical ventilation [MV] = 9%, intensive care unit [ICU] = 26%) or patients treated >2 days after admission (death = 2%, MV = 14%, ICU = 32%) than in patients treated earlier (treated on admission: death = 1%, MV = 5%, ICU = 23%, treated within 2 days of admission: death = 1%, MV = 7%, ICU = 27%). Conclusions: We identified important trends in influenza severity related to treatment timing in a large inpatient dataset, laying the groundwork for the use of this and other inpatient EMR data for influenza and other respiratory virus surveillance.