Infliximab for Paradoxical Reactions in Pediatric Central Nervous System Tuberculosis. (5th October 2021)

• Record Type: Journal Article
• Authors: Abo, Yara-Natalie; Curtis, Nigel; Osowicki, Joshua; Haeusler, Gabrielle; Purcell, Rachael; Kadambari, Seilesh; De Wachter, Matthias; Vanden Driessche, Koen; Dekeyzer, Sven; Coleman, Lee; Crawford, Nigel; Graham, Steve; Marais, Ben; Gwee, Amanda
• Is Part Of: Journal of the Pediatric Infectious Diseases Society. Volume 10:Number 12(2021)
• Page Start: 1087
• Page End: 1091
• Publication Date: 2021-10-05
• Subjects: central nervous system tuberculosis -- infliximab -- paradoxical reaction -- tuberculous meningitis; Communicable diseases in children -- Periodicals; Children -- Diseases -- Periodicals; 618.929
• DOI: 10.1093/jpids/piab094
• Languages: English
• ISSNs: 2048-7193

Abstract

Abstract: Paradoxical reactions in central nervous system tuberculosis (CNS-TB) are associated with significant morbidity and mortality. We describe 4 HIV-uninfected children treated for CNS-TB with severe paradoxical reactions unresponsive to corticosteroids. All made recovery after treatment with infliximab, highlighting the safety and effectiveness of infliximab for this complication, and need for prospective trials.